WebFeb 6, 2024 · The applications of AI-assisted transcriptomics in cancer research. Transcriptomic technologies have become powerful tools to profile the cancer transcriptome at both bulk and single-cell levels. Currently, AI approaches have been pivotal in exploiting the big data generated by transcriptomic analysis. WebJan 16, 2024 · Single-cell sequencing and transcriptome analysis can effectively characterize tumor heterogeneity to better study the mechanism of occurrence and development. In t … Integrated analysis of single-cell RNA-seq and bulk RNA-seq unveils heterogeneity and establishes a novel signature for prognosis and tumor immune …
Frontiers Analysis of Bulk RNA Sequencing Data Reveals Novel ...
WebAbstract. Single-cell transcriptome sequencing (scRNA-seq) is an unparalleled technology in the field of transcriptomics, which can study cells in a comprehensive and unbiased manner, thus characterizing complex biological processes at the cellular level. At the same time, scRNA-seq can produce a large amount of experimental data; therefore ... WebWhole-transcriptome analysis is of growing importance in understanding how altered expression of genetic variants contributes to complex diseases such as cancer, … taking nesting box out for rabbit
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WebThe analysis of TCGA dataset of large-scale esophageal tumor samples showed that the three candidate genes AHNAK2, LAMA5 and EVPL were highly expressed in ESCC tumors (Figure 4A–C). To further investigate the role of these genes in radioresistance, we conducted siRNA knockdown of AHNAK2, EVPL and LAMA5 in ESCC cell lines and … WebJan 13, 2024 · Bulk transcriptome analysis is used to study cell populations providing average expression levels for genes across large cell populations. However, these methods provide limited information about heterogeneous systems, including complex tissues consisting of various cell types or for cell types that are rare in a tissue. WebJan 1, 2024 · However, in the bulk tumor transcriptome data analysis, we found that high-stemness cancers were less immunogenetic and had a less active anti-tumor immune microenvironment than low-stemness cancers, an observation conflicting with that in single cancer cells. The main reason behind this could be that high-stemness bulk tumors … taking newborn outside in winter