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Chloroethylnitrosoureas

WebMar 1, 1986 · The chloroethylnitrosoureas (CENUs) represent a class of bifunctional alkylating agents that have proved clinically useful for cancer chemotherapy. The group includes carmustine (BCNU), lomustine ... WebChloroethylnitrosoureas are anticancer agents that undergo chemical reactions in vitro and in vivo to form active alkylating agents. The rate at which lipophilic chloroethylnitrosourease decompose in serum is faster than in aqueous solution and comparable to in vivo clearance rates.

Influence of the Expression Level of O6-Alkylguanine-DNA ...

WebJul 21, 2014 · Chloroethylnitrosoureas (CENUs) are bifunctional alkylating agents widely used for the clinical treatment of cancer. They exert anticancer activity by inducing DNA interstrand cross-links (ICLs) within GC base pairs to form dG-dC cross-links. This lesion inhibits DNA double strand separation during replication and transcription and results in ... WebMar 23, 2015 · Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine DNA base pair. However, the formation of dG-dC crosslinks can be prevented by O6-alkylguanine-DNA alkyl … tall king bed frame with storage https://peoplefud.com

Chloroethylnitrosourea - an overview ScienceDirect Topics

WebWe investigated the relative contribution of the two Escherichia coli DNA alkyltransferases (ATases) to the increased sensitivity of ATase-deficient bacteria to the mutagenic and lethal effects of chloroethylnitrosoureas (CNU). The ogtencoded protein was the principal determinant in resistance to th … WebAbstract. Chloroethylating nitrosoureas (CNU), such as lomustine, nimustine, semustine, carmustine and fotemustine are used for the treatment of malignant gliomas, brain … WebChloroethylnitrosoureas (CENUs) are an important family of chemotherapies in clinical treatment of cancers, which exert antitumor activity by inducing the formation of DNA interstrand crosslinks (dG-dC ICLs). However, the drug resistance mediated by O6-alkylguanine-DNA alkyltransferase (A … tall kitchen appliance cabinets

Investigation of resistance to DNA cross-linking agents in …

Category:Sci-Hub Investigations on the Effect of O6-Benzylguanine on the ...

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Chloroethylnitrosoureas

Chloroethylnitrosourea - What does …

WebThis paper provides an overview of cancer chemotherapy with special reference to the pharmacokinetics of the nitrosoureas. At physiological PH, the chloroethylnitrosoureas can be decomposed into an isocyanate and 2-chloroethyl diazene hydroxide. Therefore, it is clear that they have both alkylation … WebMar 23, 2015 · Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a guanine-cytosine ...

Chloroethylnitrosoureas

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WebInvestigations on the Effect of O6-Benzylguanine on the Formation of dG-dC Interstrand Cross-Links Induced by Chloroethylnitrosoureas in Human Glioma Cells Using Stable Isotope Dilution High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. Chemical Research in Toxicology, 27(7), 1253–1262. … WebApr 15, 2024 · Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation DNA interstrand cross-links (ICLs) are essential for the antitumor activity of chloroethylnitrosoureas (CENUs).

WebThis study compares the level of DNA-DNA interstrand crosslinking in murine bone marrow with the decrease in mean number of blood progenitor cells in mice treated with chloroethylnitrosoureas.

WebThis study compares the level of DNA-DNA interstrand crosslinking in murine bone marrow with the decrease in mean number of blood progenitor cells in mice treatedwith chloroethylnitrosoureas. WebChloroethylnitrosoureas (CENUs) are bifunctional antitumor alkylating agents, which exert their antitumor activity through inducing the formation of dG-dC interstrand crosslinks (ICLs) within DNA double strand. However, the complex process of tumor biology enables tumor cells to escape the killing t …

WebSep 1, 1987 · Abstract. DNA damage caused by methazolastone [an analogue of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide which does not require metabolic activation] was investigated in L-1210 leukemia which is sensitive to this drug and in a L-1210 subline [L-1210/N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU)] which is resistant to both …

WebCategory filter: Show All (16)Most Common (0)Technology (0)Government & Military (4)Science & Medicine (1)Business (2)Organizations (12)Slang / Jargon (0) Acronym … tall kitchen bags 13 gallonWebTemozolomide is more cytotoxic against L1210 than against a subline L1210/BCNU, resistant to chloroethylnitrosoureas. Using [methyl-3H] temozolomide we found that after 1 h exposure the amount of O6-methylguanine (O6mGua) was twice as high in L1210 than in L1210/BCNU whereas the amount of N7 mGua was approximately the same in the … tall kitchen cabinet end panelWeb@article{osti_6799524, title = {Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas}, author = {Scudiero, D A and Meyer, S A and Clatterbuck, B E and Mattern, M R and Ziolkowski, C H and Day, R S}, abstractNote = {In order to … tall kitchen bar stoolsWebCompared to 9L cells, 9L-2 cells were very resistant to the cytotoxic effects of 1,3-bis (2-chloroethyl)-1-nitrosourea, and to 2- [3- (2-chloroethyl)-3-nitrosoureido]-D … two sets of 意味WebChloroethylnitrosourea. Chloroethylnitrosourea cross-links are prevented from forming by the removal of the chloroethyl lesion from the O6 position before rearrangement or by … tall kitchen broom cupboardsWebThe U.S. Department of Energy's Office of Scientific and Technical Information two sets of traits crossedWebApr 1, 1984 · 1, (2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and other chloroethylnitrosourea anticancer agents in clinical use produce severe and cumulative bone marrow toxicity. Chlorozotocin. a glucose analogue, has demonstrated reduced hematologic toxicity while retaining full antitumor activity. two sets of twins instagram