Gfb-887 ic50
WebMay 13, 2024 · A Phase 2a Multiple Ascending, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GFB-887, a TRPC5 … WebJun 1, 2024 · FIH Ph 1 Study of TRPC5 Channel Inhibitor GFB-887 in Healthy Subjects. Official Title: A First-In-Human, Phase 1, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of GFB-887, a TRPC5 Channel Inhibitor, in Healthy Subjects. Secondary IDs: 8391348 [Covance] Study Status.
Gfb-887 ic50
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WebJul 23, 2024 · GFB-887 is a podocyte-targeting, small molecule inhibitor of transient receptor potential canonical-5 (TRPC5) designed specifically to treat patients with glomerular … WebFeb 2, 2024 · “GFB-887 demonstrated compelling benefits in preclinical models of mood and anxiety disorders, and we are delighted that Karuna will leverage its well-established expertise in developing medicines for psychiatric disorders to advance our TRPC4/5 candidates,” commented Anthony Johnson, M.D., president and chief executive officer of …
WebFeb 2, 2024 · Researchers have suggested that targeting brain TRPs could be a useful approach to developing therapeutics for psychiatric and neurogenerative disorders. GFB-887 was developed by Goldfinch to treat patients with kidney disease. The company announced positive results from the Phase II trial in February 2024. WebJun 25, 2024 · This is an open-label Phase 2 study evaluating the long term safety and tolerability of GFB-887 in patients with focal segmental glomerulosclerosis (FSGS), and treatment-resistant minimal change disease (TR-MCD) Study Overview Status Terminated Conditions Kidney Diseases Glomerulonephritis Nephritis Nephrosis Glomerulosclerosis
WebOct 22, 2024 · Goldfinch Bio is developing GFB-887 as a precision medicine for patients with kidney diseases characterized by overactivation of the TRPC5-Rac1 pathway, including focal segmental... WebFeb 3, 2024 · It intends to evaluate GFB-887 to treat mood and anxiety disorders and expects to share details regarding the development in the second half of the year. Goldfinch Bio’s assignment estate will receive an upfront payment of $15m and is eligible for milestone payments of up to $520m for each licensed TRPC4/5 candidate, from which $410m …
WebJun 30, 2024 · Goldfinch is currently advancing two programs through development: GFB-887, a first-in-class selective inhibitor of Transient Receptor Potential Canonical Channel 5 (TRPC5) and GFB-024, a...
WebOct 1, 2024 · GFB-887 is a podocyte-targeting, small molecule TRPC5 inhibitor designed specifically to treat patients with kidney diseases characterized by an overactivation of … hawaiian background for teamsWebNational Center for Biotechnology Information hawaiian backgroundWebAug 10, 2024 · About GFB-887. GFB-887 is a once-daily, oral TRPC5 ion channel inhibitor in clinical development for the treatment of kidney diseases, including FSGS, TR-MCD and DN. TRPC5 is a calcium-permeable ... bosch integrated 50/50 fridge freezers ukWebJun 6, 2024 · In vitro & in vivo transplanted under athymic rat kidney capsule, differentiated organoids were characterized using single cell RNA sequencing (scRNA-Seq), NanoString, & immunofluorescence techniques. Immunofluorescence quantitative analysis of aggregated actin per in vitro organoid in a protamine sulfate (PS) podocyte injury model was used to … bosch integrated dishwasher 450mmWebJul 6, 2024 · This is an open-label Phase 2 study evaluating the long term safety and tolerability of GFB-887 in patients with focal segmental glomerulosclerosis (FSGS), and … hawaiian baby woodrose seeds psychonautWebOct 6, 2024 · Key Focal Segmental Glomerulosclerosis Therapies: Sparsentan, DMX-200, GFB-887, VX-147, PF-06730512, and others The Focal Segmental Glomerulosclerosis epidemiology based on gender analyzed that... bosch integrated condenser tumble dryerWebJul 7, 2024 · In February 2024, Goldfinch Bio announced treatment with GFB-887 in an ongoing Phase 2 clinical trial demonstrated a statistically significant, clinically meaningful … bosch integrated combination microwave