Lithoplocamia lithistoides
Web1 apr. 2014 · PM060184 belongs to a new family of tubulin-binding agents originally isolated from the marine sponge Lithoplocamia lithistoides. This compound is currently produced by total synthesis and is under evaluation in clinical … Web10 jul. 2013 · Paclitaxel is arguably the most well-known and commercially successful mitosis inhibitor; intriguingly, these new compounds isolated from the Madagascan sponge Lithoplocamia lithistoides show a distinct biochemical mechanism of …
Lithoplocamia lithistoides
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Web11 dec. 2024 · At difference with the above cited phase II anticancer drugs, plocabulin (PM060184) is not an ADC but it is a Lithoplocamia lithistoides sponge-derived polyketide which acts as a very potent antimitotic agent, binding to a specific β-tubulin site with possible activity on tumors resistant to other tubulin inhibitors . Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. …
Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. Guided by the reported binding mode, several new analogs of plocabulin have been designed through removing the right aliphatic chain and further modifying on the group and the … WebGlobal Biodiversity Information Facility. Free and Open Access to Biodiversity Data.
Web1 dec. 2015 · PM050489 is a tubulin-binding agent originally isolated from the marine sponge Lithoplocamia lithistoides. This compound binds with very high affinity to β-tubulin at a new site, disrupting the microtubule network and impairing its function during divison, which leads to mitotic aberrations. WebLithoplocamia lithistoides Dendy, 1922 AphiaID 167995 (urn:lsid:marinespecies.org:taxname:167995) Classification Biota Animalia (Kingdom) …
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WebDendy, A. (1922). Report on the Sigmatotetraxonida collected by H.M.S.'Sealark' in the Indian Ocean. In: Reports of the Percy Sladen Trust Expedition to the ... arman gupta bvfWebGenus: Lithoplocamia Species (6): L. atlantica – L. dolichosclera – L. indica – L. lithistoides – L. minor – L. tuberculata. Name . Lithoplocamia Dendy, 1922 References … arman hakimianWebLithoplocamia lithistoides en Lithoplocamia · Bekijk meer » Unionpedia is een concept map of een semantisch netwerk organiseerde als een encyclopedie of een … arman guptaWebAn Lithoplocamia lithistoides in uska species han Porifera nga ginhulagway ni Arthur Dendy hadton 1922. An Lithoplocamia lithistoides in nahilalakip ha genus nga … arman hakobyan modern hebrewWebLithoplocamia lithistoides is 'n sponsspesie in die taksonomiese indeling van die Demospongiae (gewone sponse). Die liggaam van die spons bestaan uit kieselnaalde … arman hadaeghWebPHASE I STUDIES First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors Elena Elez1 & Carlos Gomez-Roca2 & Arturo Soto Matos-Pita3 & Guillem Argiles1 & Thibaud Valentin2 & Cinthya Coronado3 & Jorge Iglesias3 & Teresa Macarulla1 & Sarah Betrian2 & Salvador Fudio3 & Katrin Zaragoza3 & Josep … arman hakim nasutionWebLithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili … arman hajati