Phenanthrol
WebAug 28, 2024 · Introduction. 9-Phenanthrol, known as a phenanthrene derivative, is first described as a specific inhibitor of the transient receptor potential melastatin 4 channel, which refers to a Ca 2+-activated non-selective cation channel that is widely expressed in mammalian tissues (Grand et al., 2008).It shows no effect on the closely related TRPM5 … Web9-Phenanthrol is a selective TRPM4 blocker (IC 50 = 20 μ M in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. Technical Data for 9-Phenanthrol The technical data provided above is for guidance only.
Phenanthrol
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Web9-phenanthrol is a recently identified inhibitor of the transient receptor potential melastatin (TRPM) 4 channel, a Ca(2+) -activated non-selective cation channel whose mechanism of … Web
WebJun 27, 2024 · 9-phenanthrol, also named 9-hydroxyphenanthrene, phenanthrene-9-ol, or 9-phenanthrenol (C 14 H 10 O), is an aromatic compound from phenanthrene. 9-phenanthrol is a widely used TRPM4 (transient receptor potential melastatin 4) … WebPhenanthrol - an overview ScienceDirect Topics Phenanthrol Similarly, 1- (1,10-phenanthrol-5-ylmethyl)cyclam forms a tris (1,10-phenanthroline)RuII pendant. From: …
http://www.delta-f.com/details/1166887 WebSynonym(s): TRPM4 inhibitor, 9-Phenanthrol. Empirical Formula (Hill Notation): C 14 H 10 O. CAS No.: 484-17-3. Molecular Weight: 194.23. Compare Product No. Description SDS Pricing; 648492: The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is ...
WebTRPM4 inhibitor, 9-Phenanthrol. Synonym(s): TRPM4 inhibitor, 9-Phenanthrol. Empirical Formula (Hill Notation): C 14 H 10 O. CAS No.: 484-17-3. Molecular Weight: 194.23. Compare Product No. Description SDS Pricing; 648492: The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This ...
WebApr 9, 2024 · ( a) A monopolar stimulating electrode was placed in stratum radiatum to stimulate the Schaffer collateral axons and evoke EPSCaTs in spines and dendrites of CA1 neurons expressing GCaMP6f. and... support zaqWebFeb 6, 2024 · The higher concentration of 9-phenanthrol displayed a greater efficacy, consistent with the effects of the two concentrations tested independently (Fig. 3, A and B, and Table 1, and 30 μM data in Ref. 55). The inhibitory effects of 9-phenanthrol were concentration (30 vs. 100 μM) and membrane potential (negative vs. positive) dependent. barber bagWebPredicted data is generated using the US Environmental Protection Agency s EPISuite™. Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = 3.86 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 363.13 (Adapted Stein & Brown method) Melting Pt (deg C): 121.39 (Mean or Weighted MP) … barber bad rappenauWebNov 1, 2013 · Recently, a novel selective TRPM4 channel inhibitor, 9-phenanthrol, has been described. 9, 10, 15, 22, 23 Thus, 9-phenanthrol is an important pharmacological tool that could be used to investigate the TRPM4 channel physiological role in DSM excitability. 9, 10 Use of this novel selective pharmacological inhibitor has allowed us to show that ... support.zaq.ne jpWebThe phenanthrene-derivative 9-phenanthrol is a recently identified inhibitor of the transient receptor potential melastatin (TRPM) 4 channel, a Ca (2+) -activated non-selective cation … support.zaq.ne.jp/tool9-Phenanthrol (9-Hydroxyphenanthrene, Phenanthren-9-o, 9-Phenanthrenol) is a selective TRPM4 inhibitor with an IC50 in the range of 0.02 μM, wit... Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations. Selleckchem.com Close Choose Your Country or Region United States Germany China Japan United … barber badranWebMay 26, 2024 · The fact that 20–30 μ M 9-phenanthrol inhibited insulin secretion is consistent with the fact that the inhibition of insulin secretion was due to the inhibition of the TRPM4 channels because the IC 50 of 9-phenanthrol for the transfected or the endogenous TRPM4 channels has been shown to be 20–30 μ M in many cells [ 5, 6 ]. support zaq.ne.jp