WebSep 1, 2024 · Given the strong connection between prolonged T1IFN/IFNAR-induced STAT4 activation and lysosomal mTORC1 activation only in Stat1 −/− CD8 + T cells, it is tempting to speculate that the similar phenomena may also occur in WT CD8 + T cells by IL-12/IL-12R engagement, as this cytokine induces STAT4, but not STAT1, activation. WebOct 15, 2002 · Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling In this study we demonstrated that CD4(+) T cells from STAT4(-/-) mice exhibit reduced IL-12R expression and poor IL-12R signaling function.
Research Associate, RESEARCH: T CELL IMMUNOLOGY, CAR T CELL
WebApr 14, 2024 · The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pathway has been heavily investigated due to … WebMar 13, 2024 · ( A) Representative dot plots of naïve and effector and memory cells T cells from the spleens of WT and DKO mice (top). Populations are represented as means ± SD. Frequencies and numbers of naïve and effector memory CD4 and CD8 T cells in steady-state mice ( n = 6 to 11) (bottom). prince of persia warrior within bug
STAT4基因多态性与乙型肝炎病毒感染相关性肝细胞癌易感性的关系
WebMay 3, 2012 · Shin et al. (2005) proposed that, in T cells, regulation of STAT4 expression is associated with DNA hypermethylation rather than promoter polymorphisms. Yap et al. (2005) identified Ikaros (IKZF1; 603023)-binding elements in the 5-prime flanking regions of pufferfish, mouse, and human STAT4. Transactivation, electrophoretic mobility shift, and ... WebJul 1, 2024 · Intriguingly, STAT4 was not only strikingly expressed in HR , but also significantly enriched in T cells, illustrating that STAT4 mainly conducted HR rejection in T cells . It is well documented that STAT4 is a member of the STAT family, which are identified as the major components of DNA-binding proteins that activate gene transcription in ... WebApr 10, 2024 · Genetic studies have reported that gain-of-function variants of JAK2, TYK2, STAT1, STAT3, and STAT4 are associated with both UC and Crohn’s disease [Citation 13–18]. In addition, ... T cell proliferation and survival T cell memory and regulatory cell function B cell function Wound healing: EPO: erythropoietin; G-CSF: granulocyte colony ... prince of persia warrior within 4k