Tgif1 cancer
WebTGIF1_ENST00000407501 - Explore an overview of TGIF1_ENST00000407501, with a … WebExpression of TGIF1 (HPE4, TGIF) in cancer tissue. The cancer tissue page shows …
Tgif1 cancer
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Web23 Aug 2024 · TGIF1 is expressed in the two principal ovarian somatic cell populations: the cortex and the pre-granulosa cells of the medulla. TGIF1 expression is associated with an ovarian phenotype in estrogen-mediated sex reversal experiments. Targeted misexpression and gene knockdown indicate that TGIF1 is required, but not sufficient, for proper ovarian ... Web24 Mar 2024 · Twelve dose-sensitive genes existed in the short arm of chromosome 18 , with TGIF1 being one of them. Mutations in or absence of TGIF1 can cause HPE, anencephaly, and pituitary dysplasia. TGIF1 is expressed in the fetal and adult nervous system, and its deletions have been related to diseases of the central nervous system. …
Web21 Mar 2024 · TGIF1 (TGFB Induced Factor Homeobox 1) is a Protein Coding gene. … Web9 Apr 2024 · Osteoclast activation is a hallmark of breast cancer-induced bone disease …
Web24 Jun 2015 · Transforming growth factor beta-inducing factor 1 (TGIF1) was reported to be dysregulated in several types of cancer. However, its expression pattern and functions in nonsmall cell lung cancer (NSCLC) remained unknown. In the present study, the expression of TGIF1 was found to be elevated in the clinical NSCLC tissues. WebSmad2 with TGIF1 was strongly increased in the existence of TGFβ (Fig. 3B). Interestingly, phosphorylation of Smad2 was decreased when more TGIF1 interacts with Smad2 (Fig. 3C), suggesting that ...
Web28 Jul 2024 · Abstract. TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting with Smad2-Smad4 complexes. We found that the complex structure of TGIF1–HD bound to the TGACA motif revealed a combined binding mode that involves the HD core and the major groove, on the one hand, and the amino-terminal (N …
WebReproductive function is controlled by the pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH), which regulates the expression of the gonadotropins luteinizing hormone (LH) and FSH in pituitary gonadotropes. Paradoxically, FSHβ our behavior is a product of our beliefWeb23 Nov 2024 · TGIF1 is a transcriptional repressor playing crucial roles in human development and function and is associated with holoprosencephaly and various cancers. TGIF1-directed transcriptional repression of specific genes depends on the recruitment of corepressor SIN3A. However, to date, the exact region of TGIF1 binding to SIN3A was not … our beliefs and values tend to provideWeb2 May 2012 · Despite advances in radiation delivery protocols, exposure of normal tissues during the course of radiation therapy remains a limiting factor of cancer treatment. If the canonical TGF-β/Smad pathway has been extensively studied and implicated in the development of radiation damage in various organs, the precise modalities of its … rod wave you had me but you lost meWeb15 Oct 2024 · Loss of Tgif1 in mice increases quiescence in bone marrow HSCs and enhances long‐term repopulating activity without an effect on steady‐state haematopoiesis. 12 In MLL‐rearranged AML, which is typically aggressive and portends a poor prognosis, TGIF1 expression is decreased compared to AML cases characterized by other molecular … our behaviour is the mother of foe and friendWebTGIF1 THAP11 TM9SF2 TMED4 TMEM165 TMIGD3 TNPO1 TOE1 TP53 TPR TSKS U2AF2 UBE2D4 UBE2H USF2 UTP15 VAC14 VBP1 VHL VPS39 VWA9 WDR1 WDR26 WDR44 WRAP53 YES1 ZBTB14 ZFP36L1 ZFR ZNF787 originSystem ... and of recurrent hits, per EGFR-mutant lung cancer cell line. S1E Results of pathway enrichment analysis with … our belonging treeWebThe gene view histogram is a graphical view of mutations across TGIF1. These mutations … our behavior is the manifestation of whatWebTGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer … our beloved boy damilola